OBSERVATIONS ON ORGANIZATION OF Z-DISK COMPONENTS AND ON ROD-BODIES OF Z-DISK ORIGIN
نویسندگان
چکیده
منابع مشابه
Observations on Organization of Z-disk Components and on Rod-bodies of Z-disk Origin
Current concepts of Z-disk fine structure are based on studies by Knappeis and Carlsen (1), FranziniArmstrong and Porter (2), Reedy (3), and Kelly (4) . Knappeis and Carlsen found that I filaments terminated adjacent to the disk and, in cross-section, were positioned in corners of I squares with 220 f 35 A sides . Each I filament from one side of the disk faced the geometric center of the space...
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Titin is a giant filamentous protein traversing the half sarcomere of striated muscle with putative functions as diverse as providing structural template, generating elastic response, and sensing and relaying mechanical information. The Z-disk region of titin, which corresponds to the N-terminal end of the molecule, has been thought to be a hot spot for mechanosensing while also serving as anch...
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The Z-disk, a fascinating structure in myofibrils, demarcates sarcomeres and serves as not only a mechanical focal point but also a likely signaling nexus in mediating and regulating the functions of striated muscle. In the Z-disk, the barbed end of actin filaments and the titin filaments from the 2 opposing sarcomeres are cross-linked primarily by -actinin, allowing transmission of tension bet...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1971
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.48.2.431